Shotgun Sequencing of the Human Genome
- 5 June 1998
- journal article
- policy
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 280 (5369) , 1540-1542
- https://doi.org/10.1126/science.280.5369.1540
Abstract
The recent public announcement by TIGR and Perkin-Elmer that they intend to form a new company whose goal is to sequence the human genome four years faster and at lower cost than the government-backed Human Genome Project caught the immediate attention of the community. Venter et al. now describe the scientific rationale for their proposal and outline the business plan of the company.This publication has 15 references indexed in Scilit:
- The complete genome of the hyperthermophilic bacterium Aquifex aeolicusNature, 1998
- Generation and analysis of 280,000 human expressed sequence tags.Genome Research, 1996
- A new strategy for genome sequencingNature, 1996
- A comprehensive genetic map of the human genome based on 5,264 microsatellitesNature, 1996
- An STS-Based Map of the Human GenomeScience, 1995
- The Minimal Gene Complement of Mycoplasma genitaliumScience, 1995
- Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae RdScience, 1995
- TIGR Assembler: A New Tool for Assembling Large Shotgun Sequencing ProjectsGenome Science and Technology, 1995
- Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.Proceedings of the National Academy of Sciences, 1992
- Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome ProjectScience, 1991