Trypsin-Like Inhibitor Activity in Mouse Uteri during Early Gestation and Delayed Implantation

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Abstract
Specific activities of trypticlike inhibitors (TLI) in 27,000 g supernatant solutions of mouse uterine homogenates were determined for the following conditions: nonpregnant, pregnant and delayed implantation. Quantification of inhibitors was achieved by a fluorometric kinetic assay. Inhibitor levels in uteri from day 4 pregnant and from delayed implantation mice were the same as nonpregnant uterine control values. A significant increase in inhibitor activity (P = 0.05) was found in uteri from day 6 pregnant mice. This increased activity returned to control levels by day 12 of pregnancy. Possible functions of TLI in regulating proteolytic activity associated with early development and implantation are discussed.