THE REGULATION OF RESPIRATION

Publisher Website
Google Scholar
Abstract
Hemorrhage elicited increased alkalinity of the arterial and increased acidity of the venous blood. This was accompanied by decreased O comsumption and increased pulmonary ventilation. Reinjection increased the acidity of the arterial and decreased that of the venous blood. This was accompanied by increased O consumption and decreased pulmonary ventilation. The same directional changes in blood acidity may occur with hemorrhage and reinjection during constant artificial ventilation. The fact that venous blood more acid than normal may leave the lungs more alkaline than normal during constant pulmonary ventilation indicates the importance of flow in the pulmonary circuit. The fact that highly alkalinized blood returns from the tissues more acid than normal indicates the importance of systemic flow. The results of these experiments agree with the common inverse relation between acidity of the arterial blood and respiratory movements. The relation between acidity of the venous blood and pulmonary ventilation was more direct. Decreased O consumption during hemorrhage and excessive consumption following reinjection suggest increased production and accumulation of acid in the respiratory center during hemorrhage. The increased acidity of the venous blood suggests the same. The findings here reported support the view of the importance of acidity in the control of pulmonary ventilation but they do not necessarily preclude other effects of altered oxidations.

This publication has 1 reference indexed in Scilit: