Contact interaction between lymphocytes is a general event following activation and is mediated by LFA‐1

Publisher Website
Google Scholar
Abstract
When lymphocytes are activated in vitro, discrete cell‐cell contacts are initiated which result in cluster formation. This contact interaction is found in syngeneic or allogeneic mixed leukocyte reactions as well as in mitogen‐stimulated cultures (concanavalin A, periodate, lipopolysaccharide). T cells as well as B cells display the binding phenomenon. This activation‐dependent lymphocyte‐lymphocyte adhesion involves LFA‐1, since monoclonal antibodies (including Fab fragments) against this molecule inhibit adhesion between clustering lymphocytes in a dose‐dependent manner, whereas antibodies directed to several other cell surface antigens are inactive. Since a wide variety of functional interactions are inhibited by antibodies to LFA‐1, it may be concluded that LFA‐1‐mediated cell contact is a discrete and essential step between a recognition event and the generation of functional activities by lymphocytes in general.

This publication has 24 references indexed in Scilit: