Immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans

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Abstract
A new vaccine of ribosomal nature associated with glycoprotein cell walls from Klebsiella pneumoniae which served as an immunoadjuvant was studied. This vaccine was administered by the aerosol route to working men free of any important disease, especially of respiratory disease. A total of 104 men working for the Commissariat a l''Energie Atomique, all volunteers, were randomly placed into 2 groups. During the 1st period, 51 patients (group I) were vaccinated 3 times a week during 5wk; the 2nd group was used as control. During the 2nd period, which started on day 225, the control group received the vaccine, and the 1st group was revaccinated. A significant difference in the immunity of the 2 groups was observed. The specific antibodies increased with vaccination as illustrated by chi-square test (Yates correction), which corresponds to an independent probability equal to 0 (P = 0.5 .times. 10-4).