Targeting XIAP for the treatment of malignancy
- 2 December 2005
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 13 (2) , 179-188
- https://doi.org/10.1038/sj.cdd.4401826
Abstract
X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family of caspase inhibitors that selectively binds and inhibits caspases-3, -7 and -9, but not caspase-8. As such, XIAP blocks a substantial portion of the apoptosis pathway and is an attractive target for novel therapeutic agents for the treatment of malignancy. Antisense oligonucleotides directed against XIAP are effective in vitro and are currently being evaluated in clinical trials. Small molecule XIAP inhibitors that target the baculovirus IAP repeat (BIR) 2 or BIR 3 domain are in preclinical development and are advancing toward the clinic. This review will discuss the progress being made in developing antisense and small-molecule XIAP inhibitors.Keywords
This publication has 70 references indexed in Scilit:
- Reversible Contraception like Activity of Embelin in Male Dogs (Canis indicus Linn)Andrologia, 2009
- ABL Mutations in Late Chronic Phase Chronic Myeloid Leukemia Patients With Up-Front Cytogenetic Resistance to Imatinib Are Associated With a Greater Likelihood of Progression to Blast Crisis and Shorter Survival: A Study by the GIMEMA Working Party on Chronic Myeloid LeukemiaJournal of Clinical Oncology, 2005
- Survivin as a target for new anticancer interventionsJournal of Cellular and Molecular Medicine, 2005
- Downregulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cellsCancer Gene Therapy, 2005
- A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell DeathScience, 2004
- Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by SmacJournal of Biological Chemistry, 2003
- Survivin, versatile modulation of cell division and apoptosis in cancerOncogene, 2003
- Identification of ubiquitination sites on the X-linked inhibitor of apoptosis proteinBiochemical Journal, 2003
- HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis ProteinsJournal of Biological Chemistry, 2002
- Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic StimuliScience, 2000