Time dependence of activation of muscle AMP‐aminohydrolase by substrate and potassium ion
- 1 November 1968
- journal article
- Published by Wiley in FEBS Letters
- Vol. 2 (1) , 65-68
- https://doi.org/10.1016/0014-5793(68)80102-4
Abstract
Under the conditions where the reaction was examined, the enzyme at time zero had less than 10% of the activity of the fully active enzyme. The time course for activation with K+ followed a first order process with a rate constant of 10.6 sec−1 at 20°C. A simple mechanism consistent with the data and capable of explaining the sigmoid dependence of initial velocities versus substrate concentrations observed in steady state kinetics was proposed.Keywords
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