Transsphenoidal microsurgical removal of 250 pituitary adenomas

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Abstract
In a series of 250 pituitary adenomas, 72 (28.8%) were nonsecreting and 178 (71.2%) produced a hypersecretion syndrome: human growth hormone (83), prolactin (59) and ACTH (36). One-fifth received prior treatment and 1/4 had visual impairment. The technical aspects of the transsphenoidal procedure are given with separate consideration of microadenomas and larger tumors. The results are provided in summary form with emphasis on the favorable outcome following removal of microadenomas. There was 1 postoperative death, and the complications observed after operation are presented.