Conditioned taste aversion as a function of age in mature male rats

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Abstract
Experimental groups of young mature (90-120 days), mature (365-395 days), and aged (730-760 days) Fischer-344 rats were allowed to drink a saccharin solution followed by Li Cl toxicosis initiated at 1 of 3 intervals, either 15, 60 or 240 min. Control groups were given saline placebos according to the same schedule. In a preference test conducted 48 h after conditioning, there was little evidence of age differences in the acquisition of a saccharin aversion. Age differences were noted in the extinction of the aversion which was tested by monitoring preference over a period of 32 days of continuous access to saccharin and water. Older animals tended to show greater resistance to extinction.

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