Prostaglandin-Metabolizing Enzymes During Pregnancy: Characterization of NAD+-Dependent Prostaglandin Dehydrogenase, Carbonyl Reductase, and Cytochrome P450-Dependent Prostaglandin Omega-Hydroxylase
- 1 January 1996
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Biochemistry and Molecular Biology
- Vol. 31 (2) , 101-126
- https://doi.org/10.3109/10409239609106581
Abstract
Prostaglandins E2 and F2α regulate a number of physiological functions in reproductive tissues, and concentrations of these bioactive modulators increase during pregnancy. Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an increase in enzymes that metabolize these agents. Three prostaglandin-metabolizing enzymes induced during pregnancy are NAD+ -dependent 15-hydroxyprostaglandin dehydrogenase (PGDH), NADPH-dependent carbonyl reductase, and cytochrome P450-dependent prostaglandin Ω- or 20-hydroxylase. This review discusses the biochemical properties, regulation, and possible functions of these three enzymes.Keywords
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