Desferrioxamine as a lipid chain‐breaking antioxidant in sickle erythrocyte membranes

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Abstract
The mechanism of action of desferrioxamine in the inhibition of the catalysis of iron‐induced oxidative damage has been ascribed to its ability to chelate available ferric ion (K b = 1031). However, recent work has proposed that the trihydroxamate moiety of desferrioxamine can also be involved in electron transfer reactions involving the Superoxide radical, peroxidase/hydrogen peroxide mixtures and ferryl myoglobin radicals. In this study we report evidence for the ability of desferrioxamine to inhibit peroxidative damage to pathological membranes with which non‐haem iron is associated through a mechanism of action as a lipid chain breaking antioxidant, independently of its iron chelating properties.