Effect of Blood Volume Changes on Renin-Like Activity in Blood

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Abstract
Summary By means of the isovolemic cross-circulation technique rapid variations in concentration of renin-like activity in blood were demonstrated following marked alterations of the intravascular volume. Bleeding leads within 10 to 15 minutes to a 3- to 4-fold increase in concentration of renin-like substance in the blood, while over-transfusion results in a reduction of this activity within 24 hours. Nephrectomized rats do not react to hemorrhage with an increase in renin-like activity in blood. The renin content of the kidneys showed no detectable changes in bleeding as well as in overtransfusion experiments.

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