Studies in the biochemistry of micro-organisms. 86. The molecular constitution of mycophenolic acid, a metabolic product of Penicillium brevi-compactum Dierckx. Part 3. Further observations on the structural formula for mycophenolic acid
- 1 March 1952
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 50 (5) , 630-634
- https://doi.org/10.1042/bj0500630
Abstract
Exptl. evidence is recorded which establishes the constitution of the permanganate oxidation product of mycophenolic acid monomethyl ether as the anhydride of 3,4,5-tricarboxy-2,6-dimethoxyphenylglyoxylic acid. The Na salt of this acid, on further oxidation with H2O2, gives the anhydride of 4,6-dimeth-oxybenzene-l,2,3,5-tetracarboxylic acid which was believed by Clutterbuck and Raistrick (1933) to be the structure of the permanganate oxidation product of mycophenolic acid mono-methyl ether. This evidence confirms the preferred structure advanced for mycophenolic acid by Birkinshaw et al. (1948).Keywords
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