Synthesis of β-Glycosides of Glycyrrhetic Acid

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Abstract
Some analogues of glycyrrhizin were synthesized by coupling of methyl glycyrrhetate with per-O-acetylated glycosyl bromides of mono- and disaccharides by means of Koenigs-Knorr type condensation followed by deprotection. Sophorosyl and 6,6''-dideoxysophorosyl analogues were synthesized through stepwise glycosylation. The anomeric configuration of newly formed sugar-aglycone linkages of these glycosides (4a-p, and 7) were determined as .beta. on the basis of 1H- and 13C-nuclear magnetic resonance spectral data.

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