Clinical Results of Early Stage Prostatic Cancer Treated by Pelvic Lymphadenectomy and 125 Iodine Implants

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Abstract
Patients (80) with clinically early stage adenocarcinoma of the prostate were treated with pelvic lymphadenectomy and interstitial implantation of 125I seeds. A new applicator that permits greater accuracy in spacing the seeds was developed. Postoperative complications were minimal, with urinary irritability being the most common. Multiple transrectal needle biopsies were performed 12 and 18 mo. after treatment in 46 patients. The prostatic biopsies were negative for carcinoma in 61% and positive in 39% of the patients. Long-term followup is needed to correlate posttreatment biopsies with survival and to determine if patients with positive biopsies should receive further treatment.