Measles Encephalitis

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Abstract
From 1947 to 1957 inclusive, 61 patients with measles encephalitis were treated at the Philadelphia General Hospital, Northern Division. In this 11-year period, 70,943 cases of measles were reported to the Philadelphia Department of Health. Since this hospital was the only contagious disease hospital in the city, it can be assumed that the majority, if not all, patients with measles requiring hospitalization were referred to this facility. It is estimated from these statistics that the frequency of clinical encephalitis complicating measles is approximately 1/1,000 reported cases of measles. This ratio is consistent with the rate previously reported by us.1 The purpose of this study is to review the disease, its sequelae, the mortality, evaluate the therapeutic effect of immune substances including γ-globulin, and to compare the results of treatment in this group with a similar group of 50 patients in a prior period not treated with immune substances or

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