Mechanism of Antihepatotoxic Activity of Glycyrrhizin, I: Effect on Free Radical Generation and Lipid Peroxidation
- 1 August 1984
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 50 (04) , 298-302
- https://doi.org/10.1055/s-2007-969714
Abstract
Glycyrrhizin and its analogues were screened for antihepatotoxic activity by in vitro assay methods using carbon tetrachloride (CCl4)-and galactosarnine-induced cytotoxicity in primary cultured rat hepatocytes. Structure-activity relationship in these substances is discussed. The mechanism of inhibitory activity of glycyrrhizin and glycyrrhetinic acid in CCl4-produced liver damage was investigated by determining the effects of these substances on the initial steps in the sequence of events leading to liver lesion, revealing that anti-oxidative action plays an important part in the antihepatotoxic activity. 1 Liver-protective drugs, Part 14. Also Part 65 in the Tohoku University series on the validity of Oriental medicines.Keywords
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