Thyrocalcitonin and the Response to Parathyroid Hormone*

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Abstract
1) In the absence of the thyroid gland, the infusion of parathyroid hormone leads to a prompt rise in plasma calcium and to prompt increase in the rate of excretion of calcium in the urine. 2) In the presence of the thyroid gland, the parathyroid hormone-induced rise in plasma calcium is less marked; the rate of urinary calcium excretion falls initially and rises only after 20 to 30 hours of continuous parathyroid hormone infusion. 3) The infusion of exogenous thyrocalcitonin along with the parathyroid hormone into a thyroparathyroidectomized animal leads to a pattern of response similar to that seen in the animal with an intact thyroid gland. 4) Thyrocalcitonin has little apparent effect upon the immediate changes in renal function induced by parathyroid hormone. 5) We conclude that bone is a major site of action of thyrocalcitonin and that it probably inhibits bone resorption.