Multidrug transporter activity in lymphocytes
- 1 December 2004
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 143 (7) , 899-907
- https://doi.org/10.1038/sj.bjp.0705940
Abstract
Multidrug transporters play a dual role in haematopoietic cells, mediating the efflux of xenobiotics and regulating cell migration. For several reasons including the lack of specific antibodies, reports of multidrug transporter distribution on lymphocytes conflict. Murine B cells have been reported to completely lack transporter activity. Through analysis of parental and ‘knockout’ mice we show that, contrary to previous studies, murine B and T lymphocytes possess at least three active multidrug transporters and also a hitherto unrecognised drug‐specific import activity. Surprisingly, the drug specificity of P‐glycoprotein appears cell type dependent. The data indicate that a range of developmentally regulated, multidrug transporters can impose a barrier to treatment of immune disorders. British Journal of Pharmacology (2004) 143, 899–907. doi:10.1038/sj.bjp.0705940Keywords
This publication has 49 references indexed in Scilit:
- The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapyAntiviral Research, 2004
- The Membrane Lipid Environment Modulates Drug Interactions with the P-Glycoprotein Multidrug TransporterBiochemistry, 1999
- A Single Amino Acid Residue Contributes to Distinct Mechanisms of Inhibition of the Human Multidrug Transporter by Stereoisomers of the Dopamine Receptor Antagonist FlupentixolBiochemistry, 1999
- Kinetic Analysis of Calcein and Calcein−Acetoxymethylester Efflux Mediated by the Multidrug Resistance Protein and P-GlycoproteinBiochemistry, 1998
- A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo.Journal of Clinical Investigation, 1998
- The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.Journal of Clinical Investigation, 1998
- MRP gene overexpression in a human doxorubicin‐resistant SCLC cell line: Alterations in cellular pharmacokinetics and in pattern of cross‐resistanceInternational Journal of Cancer, 1995
- Heterogeneity in P‐glycoprotein (multidrug resistance) activity among murine peripheral T cells: Correlation with surface phenotype and effector functionEuropean Journal of Immunology, 1994
- BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTERAnnual Review of Biochemistry, 1993
- Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell LineScience, 1992