Effect of Methylcellulose on the Murphy-Sturm Lymphosarcoma in Rats2

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Abstract
Sprague-Dawley rats were given intraperitoneal injections of methylcellulose, a colloidal, nondye substance that is stored in the reticuloendothelial system. Injections were begun in various groups at times varying from 10 days before to 8 days after subcutaneous transplantation of Murphy-Sturm lymphosarcoma. The injections had no effect on establishment (takes) or growth of the tumor for the first 10 days after transplantation. Between the 17th and 21st days after transplantation there was complete regression in 38 of 40 rats begun on injections 10 days before transplantation, 15 of 18 rats begun on injections 1 day after transplantation, and 12 of 18 rats begun on injections 8 days after transplantation. Spontaneous regression was observed in 6 of 26 untreated controls.