Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments.

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Abstract
Using [mouse] monoclonal antibodies, the phosphoprotein of measles virus and a protein of herpes simplex virus type 1 were shown to crossreact with an intermediate filament protein of human cells. This intermediate filament protein, probably vimentin, has a MW of 52,000; the MW of the measles viral phosphoprotein and the herpes virus protein are 70,000 and 146,000, respectively. Crossreactivity was shown by immunofluorescent staining of infected and uninfected cells and by immunoblotting. The monoclonal antibody against measles virus phosphoprotein did not react with herpes simplex virus protein and vice versa, indicating that these monoclonal antibodies recognize different antigenic determinants on the intermediate filament molecule. The signifacance of these results in explaining the appearance of autoantibodies during virus infections in humans is discussed.