Changes in32P counting-rate in human and animal tumours

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Abstract
This paper presents the results of work done on a small number of patients and a series of 45 mice in which the local concentration of 32P in tumours was monitored by the use of miniature interstitial Geiger counters. The results indicate that diurnal rhythms can be seen occasionally in some human tumours (four out of nine). Significant peaks of half to two hours' duration were seen at irregular intervals in three out of nine patients. Transplanted mammary tumours in C3H mice showed neither rhythms nor consistent response to hormones; spontaneous mouse tumours exhibited diurnal rhythms in half the animals, and in a small number (three out of 12) peaks were induced by methotrexate. The size of peaks was small (usually about 15 per cent), both in patients and in the mouse tumours.