Neuraminidase Activity in HeLa Cells: Effect of Hydrocortisone

Abstract
Homogenates of HeLa cells contain neuraminidase activity. This enzyme is particle-bound, and it has a pH optimum of 4.2. Hydrocortisone-regulated cells contain two to three times as much neuraminidase as the corresponding controls. The hydrocortisone treatment also causes an increase in the cell content of β-glucuronidase and acid deoxyribonuclease.