ANTITUBULAR BASEMENT MEMBRANE ANTIBODIES AFTER RENAL TRANSPLANTATION

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Abstract
A renal transplant recipient developed antibodies reactive with the tubular basement membrane (TBM) but not glomerular basement membrane of two successive renal allografts. The specificity of the anti-TBM antibodies was confirmed by elution and absorption studies. The antibodies did not react with the patient's native kidney, suggesting that the immune response had been induced by the introduction of a TBM antigen through transplantation. Strain-specific TBM antigens have previously been identified in rats, and antibodies to these antigens can be induced by appropriate cross strain transplantation, supporting a similar hypothesis in this patient.

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