IMMUNOGLOBULIN GENE REARRANGEMENT IN ACUTE MYELOGENOUS LEUKEMIA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (10) , 4658-4660
Abstract
Cases 21, human of newly diagnosed nonlymphocytic leukemia were subjected to analysis of Ig gene organization. Although Ig gene organization is an essential property of B-lineage cells, Ig gene rearrangement was also observed in mouse T-cells and occasionally in cultured human T-cell leukemic cells. The 1st case of acute myelogenous leukemia in which .mu.-chain gene rearrangement was demonstrated is reported. This finding provides a further step in the understanding of both normal and abnormal hematopoietic cell differentiation and the heterogeneity of nonlymphocytic leukemia.