Carboxyl-directed Pegylation of Brain-derived Neurotrophic Factor Markedly Reduces Systemic Clearance with Minimal Loss of Biologic Activity
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (8) , 1085-1091
- https://doi.org/10.1023/a:1012117815460
Abstract
Purpose. Brain-derived neurotrophic factor (BDNF) was modified by carboxyl-directed protein pegylation in order to both retain biologic activity of the neurotrophin and reduce the rate of systemic...Keywords
This publication has 24 references indexed in Scilit:
- Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.Published by Elsevier ,2021
- Structure-Function Studies of Interleukin 15 using Site-specific Mutagenesis, Polyethylene Glycol Conjugation, and Homology ModelingJournal of Biological Chemistry, 1997
- Brain drug delivery of small molecules using immunoliposomesProceedings of the National Academy of Sciences, 1996
- Increased Permeability of Superoxide Dismutase at the Blood‐Nerve and Blood‐Brain Barriers with Retained Enzymatic Activity After Covalent Modification with the Naturally Occurring Polyamine, PutrescineJournal of Neurochemistry, 1996
- Functionalized Poly(ethylene glycols) for Preparation of Biologically Relevant ConjugatesBioconjugate Chemistry, 1995
- Modification of CD4 Immunoadhesin with Monomethoxypoly(Ethylene Glycol) Aldehyde via Reductive AlkylationBioconjugate Chemistry, 1994
- The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neuronsPublished by Elsevier ,1992
- Delivering Peptides to the Central Nervous System: Dilemmas and StrategiesPharmaceutical Research, 1991
- Molecular cloning and expression of brain-derived neurotrophic factorNature, 1989
- Renal tubular uptake of protein: effect of molecular chargeAmerican Journal of Physiology-Renal Physiology, 1983