Quantitative Changes of a Human Salivary Bactericidin for Lactobacilli Associated with Age.

Abstract
A lactobacillus bactericidin found in human, mixed, parotid and submaxillary salivas has been described (J. D. Res. 38: 798, 1959). Relative changes in activity levels as a function of age was studied in this investigation. Mixed saliva was collected from humans ranging in age from birth to 56 years. The newborn group included both premature and full-term infants. The specimens were assayed using the quantitative bactericidin test. The results indicated that this antilactobacillus system is lacking in the mixed saliva of premature infants and is not apparent in the majority of newborns during the first 4 days of life. With increase of age, there is an increase in the amount of bactericidin present in the saliva until the adult group''s range of activity is approximated. This occurs at about the 1st decade of life.

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