Effects of Thyropropionic Acid and 3,3′,5-Triiodothyropropionic Acid on Oxygen Consumption, Goiter Prevention and Cholesterol Biosynthesis in the Rat1

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Abstract
Thyropropionic acid (T0P) had no perceptible calorigenic or goiter prevention effects in rats. T0P at 400 mg/100 g in the rat diet for 2 weeks caused no significant change in serum or liver cholesterol from controls, but it did cause a 51 % inhibition of intraperitoneally injected acetate-l-C14 incorporation into liver cholesterol. In contrast, T3P in the rat diet in dilutions as low as 0.20 mg/100 g for 2 weeks, while elevating oxygen consumption only slightly above controls, produced a significant 27.2% lowering in serum cholesterol and inhibited incorporation of acetate-1-C14 into liver cholesterol 36.6%. T3P, like T0P, did not lower liver cholesterol content in this short time. T3P may play a multiple role in its effects on cholesterol metabolism in vivo.