Ethanol Triggers Neural Crest Apoptosis through the Selective Activation of a Pertussis Toxin–Sensitive G Protein and a Phospholipase Cβ–Dependent Ca2+ Transient
- 1 July 2005
- journal article
- research article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 29 (7) , 1237-1246
- https://doi.org/10.1097/01.alc.0000172460.05756.d9
Abstract
Background: Alcohol is a potent neurotoxin that triggers the selective apoptosis of neuronal populations in the developing fetus. For neural crest cells, clinically relevant ethanol levels (0.3%) ra...Keywords
This publication has 51 references indexed in Scilit:
- Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogasterNature Structural & Molecular Biology, 2003
- A New Mode of Ca2+ Signaling by G Protein-Coupled ReceptorsCurrent Biology, 2003
- RhoA and lysophosphatidic acid are involved in the actin cytoskeleton reorganization of astrocytes exposed to ethanolJournal of Neuroscience Research, 2003
- Ethanol‐Induced Cephalic Apoptosis Requires Phospholipase C‐Dependent Intracellular Calcium SignalingAlcohol, Clinical and Experimental Research, 2003
- βγ Dimers Mediate Synergy of Dopamine D2 and Adenosine A2 Receptor-Stimulated PKA Signaling and Regulate Ethanol ConsumptionCell, 2002
- G Protein-Coupled Receptor-Mediated Mitogen-Activated Protein Kinase Activation through Cooperation of Gαq and Gαi SignalsMolecular and Cellular Biology, 2000
- Ethanol‐Induced Neural Crest Apoptosis Is Coincident with Their Endogenous Death, But Is Mechanistically DistinctAlcohol, Clinical and Experimental Research, 1998
- Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPasesCurrent Biology, 1996
- Pertussis toxin-catalyzed ADP-ribosylation of G0.alpha. with mutations at the carboxyl terminusBiochemistry, 1992