CONTROL OF RESPIRATORY DISEASE IN RECRUITS WITH TYPES 4 AND 7 ADENOVIRUS VACCINES

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Abstract
Top., F. H., Jr., B. A. Dudding, P. K. Russell and E. L. Buescher (Walter Reed Army Institute of Research, Wash., D.C. 20012). Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines. Amer J Epidem 94: 142–146, 1971.—Simultaneous immunization of recruits in a basic combat training brigade with live adenovirus type 7 and type 4 (ADV-7, ADV-4) vaccines during an outbreak of acute respiratory disease (ARD) caused by both adenovirus types led to 95% suppression of ADV-7 associated ARD and 50% reduction in total ARD hospitalizations as compared with a brigade immunized with ADV-4 vaccine alone. A small excess of ADV-4 associated ARD hospitalizations which occurred in the study brigade may have been due in part to the relatively low potency of ADV-4 vaccine used. The combined use of ADV-4 and ADV-7 vaccines proved to be a safe and effective means of controlling ARD in a military trainee population.

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