Treatment of Spastic Paresis

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Abstract
Whenever the central nervous system is damaged, two types of symptoms and signs emerge. Negative ones, such as weakness, paralysis, fatigability, and lack of dexterity, result from either disconnection of lower motor neurons in the brain stem and spinal cord from the cerebral motor system or destruction of the neurons themselves. The second type — positive symptoms and signs — includes excessive involuntary motor activity usually associated with macroscopic lesions of the central nervous system and referred to as spasticity. Disconnection of lower motor neurons from cerebral control releases lower-level circuits, which then become overactive and produce dramatic patterns of . . .