Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies.Clinical description

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Abstract
Carcinoma of the colon occurred in four generations of a family, including two of three siblings of one generation and eight of 19 members of the next generation. In addition, uterine cancer or lymphoproliferative malignancies were found in two family members. Of 41 members of the fourth generation, two were found to have colon cancer and one had malignant lymphoma. Clinical features were similar to those patients with “cancer family syndrome.” Although a precise genetic mechanism is uncertain, it appeared to be transmitted as an autosomal dominant character.