Analysis of In-situ Hybridization Data for Unique Genes Using GLIM

1 June 1989

journal article
research article
Published by JSTOR in Biometrics

Vol. 45 (2) , 601-604
https://doi.org/10.2307/2531500

Abstract

When a radioactively-labelled gene probe is hybridized to chromosomes on a microscope slide, the site of hybridization should be revealed by counting emitted .beta.-particles on a photographic overlay. However, in some cases background radiation disguises the site of hybridization. Using GLIM to fit Poisson regression models, it is possible to determine the chromosome to which the gene has hybridized.

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