Effect of Indomethacin on Local Cerebral Blood Flow in Awake, Minimally Restrained Rats
- 29 June 1981
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 1 (2) , 233-236
- https://doi.org/10.1038/jcbfm.1981.25
Abstract
The effect of indomethacin (10 mg kg−1) on local CBF (l-CBF) was studied with autoradiographic techniques in awake, minimally restrained rats. When compared with uninjected awake control animals, those given indomethacin showed a reduction of l-CBF by 25–45%. This reduction is somewhat less pronounced than that previously obtained in paralyzed animals maintained on 70% N2O (a reduction by 30–60%). An enhancement of the indomethacin response during nitrous oxide anesthesia was mainly observed in structures which show a maintained or increased CBF during anesthesia.Keywords
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