Comparison of Mouse-Protective Tests and Chick-Protective Tests of Over 600 Chemicals Against Pasteurella Multocida

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Abstract
Summary and Conclusions: Mouse-protective tests and chick-protective tests have been used to determine possible in vivo activity for over 600 chemicals tested for in vitro activity against P. multocida by McKenzie and co-workers (1948). None of the chemicals other than the sulfonamides showed in vivo activity against Pasteurella multocida. The chemicals showing superior activity were 2-sulfanilamidopyrimidine, 2-sulfanilamidopyrazine and their chloro-, bromo-, and methyl derivatives.