Salmonella enterica Serovars Typhimurium and Dublin Can Lyse Macrophages by a Mechanism Distinct from Apoptosis
Open Access
- 1 June 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (6) , 3744-3747
- https://doi.org/10.1128/iai.68.6.3744-3747.2000
Abstract
Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene.Keywords
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