DIPHENYLHYDANTOIN AND THE RELEASE OF ADRENOCORTICOTROPIC HORMONE IN THE ALBINO RAT1

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Abstract
Rats, treated with diphenylhydantoin (Dilantin, 1OO mg./kg.) fail to show the expected depiction of adrenal ascorbic acid following unilateral adrenalectomy, intravenous Vasopressin, subcutaneous epinephrine or intraperitoncal histaminc. This blockade seems to occur in two stages, an initial phase presumably central in which the adrenal cortex maintains its ability to respond in a normal manner (by a depletion of ascorbic acid) to exogenous corticotropin; and later a second phase in which there is a reduction in the responsiveness of the adrenal itself to exogenous corticotropin.