Status Report on the Acquired Immunodeficiency Syndrome

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Abstract
HUMAN T-cell lymphotropic virus type III (HTLV-III) is a retrovirus that is currently accepted as the primary cause of the acquired immunodeficiency syndrome (AIDS). Serologic assays have been developed to detect the presence of antibody to HTLV-III; the presence of such antibodies is taken as reasonable proof of past or present infection with this agent. These assays have been used for epidemiologic studies and to screen defined populations and recently have been introduced for the screening of donated blood. Recently the Food and Drug Administration (FDA) approved three test kits, manufactured by Abbott Laboratories, North Chicago, Ill, Electro-Nucleonics Inc, Fairfield, NJ, and Litton Bionetics, Charleston, SC, for screening donated blood and plasma for antibodies to HTLV-III. These kits utilize the enzyme-linked immunosorbent assay (ELISA) technique to detect antibodies to HTLV-III, which utilizes beads or microtiter wells coated with antigens obtained from disrupted whole virus grown in the human leukemic cell

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