The separation and properties of the neurotoxins from the venom of the tiger snake Notechis scutatus scutatus

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Abstract
Two types of neurotoxin were separated from the venom of the tiger snake Notechis scutatus scutatus by means of adsorption on BaCO3, low-temperature methanol-fractiona-tion and chromatography on the Amberlite resin IRC-50. One type of neurotoxin is stationary during paper electrophoresis at pH 8.6; the other type is represented by a group of weakly anionic proteins. Both types of neurotoxin were separated from significant amounts of the components responsible for the other main pathological effects of the venom, i.e. the coagulating factor and the hemolysin, as well as the enzymes hyaluronidase, phosphatases and cholinesterase. The properties of the neurotoxins are described and discussed in relation to those of the neurotoxins of the venom of Crotalus terrificus terrificus.
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