Low Heart Rate Variability and the Effect of Depression on Post–Myocardial Infarction Mortality

Abstract
Depression is an independent risk factor for cardiac and all-cause mortality in stable coronary artery disease and after coronary artery bypass surgery, unstable angina, and acute myocardial infarction (MI).1 In a study of 222 patients by Frasure-Smith and colleagues,2 for example, major depression was associated with a 4-fold increase in the risk of mortality during the first 6 months following acute MI, after adjusting for confounders. Importantly, the prognostic significance of major depression was comparable to that of having left ventricular dysfunction or a history of MI.

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