Activation of Cytotoxic Polymorphonuclear Leukocytes by In Vivo Administration of a Streptococcal Preparation, OK-4322
- 31 May 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 72 (6) , 1365-1370
- https://doi.org/10.1093/jnci/72.6.1365
Abstract
Injection ip of a streptococcal preparation, OK-432, into WKA and DONRYU rats induced in vitro cytotoxicity of polymorphonuclear leukocytes (PMN) against tumor cells in terms of their cytostasis and cytolysis. PMN were obtained from peritoneal exudates of WKA and DONRYU rats. Cytotoxixcity of activated PMN was immunologically nonspecific, although a certain target selectivity was observed in PMN cytotoxicity. The titer of cytotoxicity of PMN was dependent on the dose of injected OK-432 and on the number of PMN in the cytotoxicity assay. Activated PMN appeared very early (6 hr) after OK-432 injection, and the cytotoxic titer of PMN decreased from 24 hours and disappeared at 96 hours after injection of the reagent. In vitro culture of PMN with OK-432 also evoked cytotoxicity of PMN.Keywords
This publication has 1 reference indexed in Scilit:
- Augmentation of Mouse Natural Killer Cell Activity by a Streptococcal Preparation, Ok-4322JNCI Journal of the National Cancer Institute, 1980