PROOF OF A HUMORAL CONTROL OF INTESTINAL SECRETION

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Abstract
Exptl. evidence from 7 dogs shows that: In transplanted loops of jejunum with original innervation and circulation (1st stage), food in the digestive tract was accompanied by a decrease in rate of secretion in 3 dogs, and an increase in 4. After complete isolation of the loop by division of the mesenteric pedicle (2d stage), food in the digestive tract was accompanied by an increased rate of secretion in all dogs but one in which there was no great change. This proves the presence of a humoral control of the rate of secretion of fluid. Enzyme production (sucrase, amylase-maltase, peptidase and lipase) was decreased by food (1st stage )in 3 dogs and increased in 4. In the 2d stage preparations feeding augmented the production in all dogs of all enzymes except sucrase in 3, peptidase in 1, and lipase in 1, proving humoral control of the secretion of these organic constituents. There is little cellular material from the mucosa in intestinal juice as collected from these transplants. Calculation shows that it is highly improbable that the enzymes found arise chiefly from disintegration of desquamated cells. The secretory activity of isolated loops is intermittent. The periods of greatest activity may be spaced 2-4 hrs. apart, which interval appears not to depend on the integrity of the extrinsic nerves of the gut.[long dash]There are at least 3 components in the control of the secretion from isolated intestinal loops; (a) local mechanical stimuli; (b) inhibitory influences exerted via some of the extrinsic nerves, and (c) humoral stimulation occasioned by digestion of food in another part of the gastro-intestinal tract.

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