Enantioselective Allyltitanation. Synthesis of (-)-Slaframine
- 14 May 2002
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2002 (07) , 951-957
- https://doi.org/10.1055/s-2002-28505
Abstract
An enantioselective synthesis of the indolizidine alkaloid (-)-slaframine from aldehyde 1 is reported. The stereogenic centers at C-1 and C-8a are introduced by an enantioselective allyltitanation and a Mitsunobu reaction. Reductive double cyclization of the acyclic compound (-)-10 affords the bicyclic skeleton of (-)-slaframine.Keywords
This publication has 0 references indexed in Scilit: