Alterations in Plasma and Brain Lipid Metabolism during Endotoxemia in the Neonatal Rat

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Abstract
Endotoxin in the neonatal rat produced marked elevations of plasma triglycerides, free fatty acids, and phospholipids. Incorporation of 3H-acetate into total lipids and cholesterol fraction of the brain was increased in rats given endotoxin, while incorporation into the phospholipid fraction in both brain and liver was decreased. These studies suggest that changes in plasma lipids provide not only a sensitive index of endotoxemia in the neonatal rat, but also reflect marked alterations in substrate utilization of the host during stress.

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