Hypoxic Cell Radiosensitizers

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Abstract
Oxygen is an important radiation sensitizer of mammalian cells. The possibility that some human neoplasms contain foci of hypoxia within which tumor cells are relatively radiation resistant has concerned radiation oncologists for many years. The presence of hypoxic foci may be one of the reasons why some human tumors are difficult to control locally with radiation. Therefore, the radiation oncologist is anxious to develop methods that render hypoxic cells as radiosensitive as oxygenated cells; success in this direction promises to yield an increased probability of local tumor control after a course of radiation therapy.In one attempt to circumvent the . . .