THE ALKALOIDS OF FUMARACEOUS PLANTS: III. A NEW ALKALOID, BICUCULLINE, AND ITS CONSTITUTION

1 February 1933

journal article
Published by Canadian Science Publishing in Canadian Journal of Research

Vol. 8 (2) , 142-146
https://doi.org/10.1139/cjr33-015

Abstract

A base, now named bicuculline, previously isolated from Dicentra cucullaria and referred to as alkaloid α has been obtained from Corydalis sempervirens and Adlumia fungosa. A chemical examination of this alkaloid has disclosed an exceptionally close relation to hydrastine, from which it differs only by the substitution of a methylenedioxy group for the two methoxyl groups. Accordingly, hydrolytic oxidation yields hydrastinine and 2-carboxy-3:4-methylenedioxy-benzaldehyde, which on reduction is converted into the known 3:4-methylenedioxy-phthalide.

Keywords

ALKALOID
CONSTITUTION
PHTHALIDE
BICUCULLINE
HYDRASTINE
DISCLOSED
CONVERTED
SEMPERVIRENS
EXCEPTIONALLY
FUMARACEOUS

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