Kinetics of induction of error-prone repair of bacteriophage λ by temperature shift in an Escherichia coli dnaB mutat
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 155 (2) , 231-234
- https://doi.org/10.1007/bf00393165
Abstract
Preincubation at 42o, before infection at permissive temperature by phage λ, of an Escherichia coli dnaB mutant, provokes a significant increase in survival and mutagenesis of ultraviolet irradiated phage as well as mutagenesis of untreated phage. Similarly to UV irradiation and many chemical mutagens, the inhibition of DNA synthesis by temperature shift of this dnaB mutant induces SOS repair. This work shows that replication blockage in bacterial DNA is not only mutagenic for bacterial DNA itself (Witkin, 1975) but also for normally replicating λ DNA, probably due to induction of diffusible products.This publication has 17 references indexed in Scilit:
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