Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
- 1 January 1998
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 15 (2) , 239-245
- https://doi.org/10.1023/a:1011914618109
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).Pharmaceutical Research, 1997
- Decomposition Pathways and in Vitro HIV Inhibitory Effects of IsoddA Pronucleotides: Toward a Rational Approach for Intracellular Delivery of Nucleoside 5‘-MonophosphatesJournal of Medicinal Chemistry, 1996
- Mononucleoside Phosphotriester Derivatives with S-Acyl-2-thioethyl Bioreversible Phosphate-Protecting Groups: Intracellular Delivery of 3'-Azido-2',3'-dideoxythymidine 5'-MonophosphateJournal of Medicinal Chemistry, 1995
- Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)Journal of Medicinal Chemistry, 1994
- Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeysAntimicrobial Agents and Chemotherapy, 1994
- Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP (dAMP) kinase from L1210 cellsBiochemical Pharmacology, 1992
- 5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivativesJournal of Biological Chemistry, 1991
- Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) CellsJournal of Pharmaceutical Sciences, 1990
- Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal MucosaPharmaceutical Research, 1990
- The Use of Cultured Epithelial and Endothelial Cells for Drug Transport and Metabolism StudiesPharmaceutical Research, 1990