Haemodynamic Action of Thymoxamine (An Alpha-adrenergic Blocking Agent) in Occlusive Peripheral Arterial Disease

1 October 1968

journal article
clinical trial
Published by Oxford University Press (OUP) in Cardiovascular Research

Vol. 2 (4) , 360-366
https://doi.org/10.1093/cvr/2.4.360

Abstract

Rapid intravenous injection of thymoxamine in patients with superficial femoral artery occlusion resulted in increased cardiac output and femoral artery flow, with lowered resistance distal to the block. Skin flow in the affected leg was increased and muscle flow showed a small increase in some patients. Blood pressure and pulse were not significantly altered.

Keywords

ADRENERGIC ALPHA-ANTAGONISTS
MOXISYLYTE
PERIPHERAL VASCULAR DISEASES
HEMODYNAMICS
FLUID FLOW
SUPERFICIAL FEMORAL ARTERY OCCLUSION
LEG
PULSE
SKIN
BLOOD PRESSURE
CARDIAC OUTPUT
HIGH
FEMORAL ARTERY
INTRAVENOUS INJECTIONS

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