Idiopathic Paroxysmal Myoglobinuria

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Abstract
Idiopathic paroxysmal myoglobinuria is a rare disorder. Adams, Denny-Brown, and Pearson1in their comprehensive treatise, "Diseases of Muscle," state that they have never seen a case. A search of the literature reveals reports of fewer than two dozén cases, to which we add observations on two others. REPORT OF CASES Case 1. —A 46-year-old white man of Irish descent was admitted to Beth Israel Hospital in July, 1948, soon after he had suddenly become incapacitated by intolerably painful cramps in his thighs; these had come on without warning when he had attempted to crawl under a fence after climbing a steep hill. He had found himself unable to rise or to straighten himself from the stooped position but had been able to sit with his legs extended. He had perspired profusely during this episode. Ever since childhood the patient had experienced weakness and pains in the muscles of arms

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